OBFBound: O'Brien-Flemming bounds for cumulative Z-test in Group Sequential Design
Description
Sequential O'Brien-Flemming upper bounds for cumulative Z-test on accumaltive data. Z values are correlated. This is usually used for group sequential design.
Usage
OBFBound(K, alpha=0.05, side=2, ti=NULL, c0=NULL)
Value
The result is a matrix.
- ti
time of test
- z
O'Brien-Flemming upper z-bound
- cum.alpha
cumulative alpha-value
Arguments
- K
count of tests including the final
- alpha
goal alpha value for the last test at time 0.
- side
1=one-side test, 2=two-side test
- ti
times for test. These should be [0, 1]. If not specified, equal interval is assumed.
- c0
correlation matrix. if not specified, Brownian motion assummed.
Author
Kyun-Seop Bae k@acr.kr
Details
It calculates O'Brien-Flemming upper z-bounds and cumulative alpha-values for the repeated test in group sequential design.
Examples
Run this code OBFBound(K=2)
OBFBound(K=3)
OBFBound(K=4)
OBFBound(K=5)
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