get_subclust_enr_hmap

Get heatmap of subtype proportion associations for each celltype/subtype and each factor

Single-cell Interpretable Tensor Decomposition (scITD) employs the
Tucker tensor decomposition to extract multicell-type gene expression patterns
that vary across donors/individuals. This tool is geared for use with single-cell
RNA-sequencing datasets consisting of many source donors. The method has a wide
range of potential applications, including the study of inter-individual variation
at the population-level, patient sub-grouping/stratification, and the analysis
of sample-level batch effects. Each "multicellular process" that is extracted
consists of (A) a multi cell type gene loadings matrix and (B) a
corresponding donor scores vector indicating the level at which the corresponding
loadings matrix is expressed in each donor. Additional methods are implemented
to aid in selecting an appropriate number of factors and to evaluate stability
of the decomposition. Additional tools are provided for downstream analysis,
including integration of gene set enrichment analysis and ligand-receptor analysis.
Tucker, L.R. (1966) <doi:10.1007/BF02289464>. Unkel, S., Hannachi, A., Trendafilov, N. T., & Jolliffe, I. T. (2011) <doi:10.1007/s13253-011-0055-9>. Zhou, G., & Cichocki, A. (2012) <doi:10.2478/v10175-012-0051-4>.

Jonathan Mitchel

scITD

Single-Cell Interpretable Tensor Decomposition

Evan Biederstedt

Peter Kharchenko

get_subclust_enr_hmap function

<dl><dt>container</dt>
<dd>environment Project container that stores sub-containers
for each cell type as well as results and plots from all analyses</dd>
<dt>all_ctypes</dt>
<dd>character A vector of the cell types to include</dd>
<dt>all_res</dt>
<dd>numeric A vector of resolutions matching the all_ctypes parameter</dd>
<dt>all_factors</dt>
<dd>numerc A vector of the factors to compute associations for</dd></dl>

Arguments

Get heatmap of subtype proportion associations for each celltype/subtype and each factor — get_subclust_enr_hmap

<dl>

<dt>container</dt>
<dd>environment Project container that stores sub-containers
for each cell type as well as results and plots from all analyses</dd>


<dt>all_ctypes</dt>
<dd>character A vector of the cell types to include</dd>


<dt>all_res</dt>
<dd>numeric A vector of resolutions matching the all_ctypes parameter</dd>


<dt>all_factors</dt>
<dd>numerc A vector of the factors to compute associations for</dd>

</dl>

get_subclust_enr_hmap: Get heatmap of subtype proportion associations for each celltype/subtype and each factor

Description

Usage

Value

Arguments