Generates cell-level cytokine activity estimates using relevant information from gene sets constructed with the 'CytoSig' and the 'Reactome' databases and scored using the modified 'Variance-adjusted Mahalanobis (VAM)' framework for single-cell RNA-sequencing (scRNA-seq) data. 'CytoSig' database is described in: Jiang at al., (2021) tools:::Rd_expr_doi("10.1038/s41592-021-01274-5"). 'Reactome' database is described in: Gillespie et al., (2021) tools:::Rd_expr_doi("10.1093/nar/gkab1028"). The 'VAM' method is outlined in: Frost (2020) tools:::Rd_expr_doi("10.1093/nar/gkaa582").
Maintainer: Azka Javaid azka.javaid.gr@dartmouth.edu
Authors:
H. Robert Frost hildreth.r.frost@dartmouth.edu