alphaspend

Calculates the upper boundaries for efficacy at each look time

S4 class object for creating and managing group sequential designs. It calculates the efficacy and futility boundaries at each look. It allows modifying the design and tracking the design update history.

Hui Zheng

seqmon

Group Sequential Design Class for Clinical Trials

alphaspend function

<dl> <dt>levels</dt>
<dd>The cumulative alpha spending at each look time
</dd> <dt>t</dt>
<dd>Normalized look times
</dd> <dt>int</dt>
<dd>The number of intervals the solution space is partitioned into
</dd> <dt>tol</dt>
<dd>Tolerance of the solution using uniroot
</dd></dl>

Arguments

Function that calculates the upper boundaries for efficacy — alphaspend

<dl>

 <dt>levels</dt>
<dd>The cumulative alpha spending at each look time
</dd>

 <dt>t</dt>
<dd>Normalized look times
</dd>

 <dt>int</dt>
<dd>The number of intervals the solution space is partitioned into
</dd>

 <dt>tol</dt>
<dd>Tolerance of the solution using uniroot
</dd>

</dl>

alphaspend: Function that calculates the upper boundaries for efficacy

Description

Usage

Value

Arguments

Examples