serocalculator (version 1.3.0)

log_likelihood: Calculate log-likelihood

Description

Calculates the log-likelihood of a set of cross-sectional antibody response data, for a given incidence rate (lambda) value.

Usage

log_likelihood(
  lambda,
  pop_data,
  curve_params,
  noise_params,
  antigen_isos = get_biomarker_levels(pop_data),
  verbose = FALSE,
  ...
)

Value

the log-likelihood of the data with the current parameter values

Arguments

lambda

a numeric vector of incidence parameters, in events per person-year

pop_data

a data.frame() with cross-sectional serology data by antibody and age, and additional columns

curve_params

a data.frame() containing MCMC samples of parameters from the Bayesian posterior distribution of a longitudinal decay curve model. The parameter columns must be named:

• antigen_iso: a character() vector indicating antigen-isotype combinations

• iter: an integer() vector indicating MCMC sampling iterations

• y0: baseline antibody level at $t=0$ ($y(t=0)$)

• y1: antibody peak level (ELISA units)

• t1: duration of infection

• alpha: antibody decay rate (1/days for the current longitudinal parameter sets)

• r: shape factor of antibody decay

noise_params

a data.frame() (or tibble::tibble()) containing the following variables, specifying noise parameters for each antigen isotype:

• antigen_iso: antigen isotype whose noise parameters are being specified on each row

• nu: biological noise

• eps: measurement noise

• y.low: lower limit of detection for the current antigen isotype

• y.high: upper limit of detection for the current antigen isotype

antigen_isos

Character vector listing one or more antigen isotypes. Values must match pop_data.

verbose

logical: if TRUE, print verbose log information to console

...

additional arguments passed to other functions (not currently used).

Examples

library(dplyr)
library(tibble)

# Load cross-sectional data
xs_data <-
  sees_pop_data_pk_100

# Load curve parameters and subset for the purposes of this example
curve <-
  typhoid_curves_nostrat_100 %>%
  filter(antigen_iso %in% c("HlyE_IgA", "HlyE_IgG"))

# Load noise params
cond <- tibble(
  antigen_iso = c("HlyE_IgG", "HlyE_IgA"),
  nu = c(0.5, 0.5), # Biologic noise (nu)
  eps = c(0, 0), # M noise (eps)
  y.low = c(1, 1), # low cutoff (llod)
  y.high = c(5e6, 5e6)
) # high cutoff (y.high)

# Calculate log-likelihood
ll_AG <- log_likelihood(
  pop_data = xs_data,
  curve_params = curve,
  noise_params = cond,
  antigen_isos = c("HlyE_IgG", "HlyE_IgA"),
  lambda = 0.1
) %>% print()