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sgRSEA (version 0.1)

Enrichment Analysis of CRISPR/Cas9 Knockout Screen Data

Description

Provides functions to implement sgRSEA (single-guide RNA Set Enrichment Analysis), which is a robust test for identification of essential genes from genetic screening data using CRISPR (clustered regularly interspaced short palindromic repeats) and Cas9 (CRISPR-associated nuclease 9) system.

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Version

Install

install.packages('sgRSEA')

Monthly Downloads

5

Version

0.1

License

GPL-2

Maintainer

Jungsik Noh

Last Published

June 15th, 2015

Functions in sgRSEA (0.1)

UQnormalize

Upper-quartile/total-count normalization of raw sgRNA read count data
sgRSEA.mean

Perform a permutation test similar to sgRSEA
melanoma808

A subset of CRISPR/Cas9 knockout screening data on melanoma cell lines
sgRSEA

Perform a permutation test which computes gene scores and their significance
plotScores

Plot histograms of gene scores
plotNScores

Plot histograms of normalized gene scores
sgCount

Generate a raw sgRNA read count table from fastq files