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sigPathway (version 1.40.0)

rankPathways: Summarizes Top Pathways from Pathway Analyses

Description

Summarizes top pathways from pathway analyses.

Usage

rankPathways(res.A, res.B, G, tab, phenotype, gsList, ngroups, methodNames = NULL, npath = 25, allpathways = FALSE)

Arguments

res.A
a list from the output of calculate.NTk or calculate.NEk
res.B
a list from the output of calculate.NTk or calculate.NEk
G
a list containing the source, title, and probe sets associated with each curated pathway
tab
a numeric matrix of expression values, with the rows and columns representing probe sets and sample arrays, respectively
phenotype
a numeric (or character if ngroups >= 2) vector indicating the phenotype
gsList
a list containing three vectors from the output of the selectGeneSets function
ngroups
an integer indicating the number of groups in the matrix
methodNames
a character vector of length 2 giving the names for res.A and res.B
npath
an integer indicating the number of top gene sets to consider from each statistic when ranking the top pathways
allpathways
a boolean to indicate whether to include the top npath pathways from each statistic or just consider the top npath pathways (sorted by the sum of ranks of both statistics) when generating the summary table

Value

A data frame showing the pathways' indices in G, gene set category, pathway title, set size, res.A's statistics, res.B's statistics, the corresponding q-values, and the ranks for the top gene sets.

Details

This function ranks together the statistics given in res.A and res.B and summarizes the top gene sets in a tabular format similar to Table 2 in Tian et al. (2005)

References

Tian L., Greenberg S.A., Kong S.W., Altschuler J., Kohane I.S., Park P.J. (2005) Discovering statistically significant pathways in expression profiling studies. Proceedings of the National Academy of Sciences of the USA, 102, 13544-9.

http://www.pnas.org/cgi/doi/10.1073/pnas.0506577102