sigminer

<ul>
<li>Author: <a href="https://shixiangwang.github.io/home/">Shixiang Wang</a> (<a href="/link/w_shixiang%40163.com?package=sigminer&version=2.0.3" data-mini-rdoc="sigminer::w_shixiang@163.com">w_shixiang@163.com</a>)</li>
<li>Please go to <a href="https://shixiangwang.github.io/sigminer-doc/">https://shixiangwang.github.io/sigminer-doc/</a> for full vignette.</li>
<li>Please go to <a href="https://shixiangwang.github.io/sigminer/reference/index.html">https://shixiangwang.github.io/sigminer/reference/index.html</a>
for organized documentation of functions and datasets.</li>
<li>Result visualization for <a rd-options="" href="/link/MAF?package=sigminer&version=2.0.3" data-mini-rdoc="sigminer::MAF">MAF</a> is provide by maftools package,
please read its <a href="https://bioconductor.org/packages/release/bioc/vignettes/maftools/inst/doc/maftools.html">vignette</a>.</li>
</ul>

Genomic alterations including single nucleotide
substitution, copy number alteration, etc. are the major force for
cancer initialization and development. Due to the specificity of
molecular lesions caused by genomic alterations, we can generate
characteristic alteration spectra, called 'signature' (Wang, Shixiang,
et al. (2020) <DOI:10.1371/journal.pgen.1009557> & Alexandrov, Ludmil
B., et al. (2020) <DOI:10.1038/s41586-020-1943-3>). This package helps
users to extract, analyze and visualize signatures from genomic
alteration records, thus providing new insight into cancer study.

Shixiang Wang

Extract, Analyze and Visualize Mutational Signatures for Genomic
Variations

Ziyu Tao

Huimin Li

Tao Wu

Xue-Song Liu

Anand Mayakonda

sigminer function

<ul>
<li>Author: <a href='https://shixiangwang.github.io/home/'>Shixiang Wang</a> (<a href='mailto:w_shixiang@163.com'>w_shixiang@163.com</a>)</li>
<li>Please go to <a href='https://shixiangwang.github.io/sigminer-doc/'>https://shixiangwang.github.io/sigminer-doc/</a> for full vignette.</li>
<li>Please go to <a href='https://shixiangwang.github.io/sigminer/reference/index.html'>https://shixiangwang.github.io/sigminer/reference/index.html</a>
for organized documentation of functions and datasets.</li>
<li>Result visualization for <a rd-options='' href='MAF'>MAF</a> is provide by maftools package,
please read its <a href='https://bioconductor.org/packages/release/bioc/vignettes/maftools/inst/doc/maftools.html'>vignette</a>.</li>
</ul>

sigminer: sigminer: Extract, Analyze and Visualize Signatures for Genomic Variations

Description

Arguments