getInit

getInit.ExponentialTransition

getInit.WeibullTransition

Retrieve Initial Parameter Vectors for Likelihood Maximization

Based on the illness-death model a large number of clinical
trials with oncology endpoints progression-free survival (PFS) and
overall survival (OS) can be simulated, see Meller, Beyersmann and
Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows
for random and event-driven censoring, an arbitrary number of
treatment arms, staggered study entry and drop-out. Exponentially,
Weibull and piecewise exponentially distributed survival times can be
generated. The correlation between PFS and OS can be calculated.

Alexandra Erdmann

simIDM

Simulating Oncology Trials using an Illness-Death Model

Kaspar Rufibach

Holger Löwe

Daniel Sabanés Bové

F. Hoffmann-La Roche AG 

University of Ulm 

getInit function

<dl><dt>transition</dt>
<dd>(<code>ExponentialTransition</code> or <code>WeibullTransition</code>) containing the initial parameters.
See <code>exponential_transition()</code> or <code>weibull_transition()</code> for details.</dd></dl>

Arguments

<ul>
<li><code>getInit(ExponentialTransition)</code>: for the Exponential Transition Model</li>
<li><code>getInit(WeibullTransition)</code>: for the Weibull Transition Model</li>
</ul>

Methods (by class)

Retrieve Initial Parameter Vectors for Likelihood Maximization — getInit

<dl>

<dt>transition</dt>
<dd>(<code>ExponentialTransition</code> or <code>WeibullTransition</code>) containing the initial parameters.
See <code>exponential_transition()</code> or <code>weibull_transition()</code> for details.</dd>

</dl>

getInit: Retrieve Initial Parameter Vectors for Likelihood Maximization

Description

Usage

Value

Arguments

Methods (by class)

Examples