getSumPCW

This returns the sum of two piecewise constant hazards per interval.

Based on the illness-death model a large number of clinical
trials with oncology endpoints progression-free survival (PFS) and
overall survival (OS) can be simulated, see Meller, Beyersmann and
Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows
for random and event-driven censoring, an arbitrary number of
treatment arms, staggered study entry and drop-out. Exponentially,
Weibull and piecewise exponentially distributed survival times can be
generated. The correlation between PFS and OS can be calculated.

Alexandra Erdmann

simIDM

Simulating Oncology Trials using an Illness-Death Model

Kaspar Rufibach

Holger Löwe

Daniel Sabanés Bové

F. Hoffmann-La Roche AG 

University of Ulm 

getSumPCW function

<dl><dt>haz1</dt>
<dd>(<code>numeric</code>) first summand (piecewise constant hazard).</dd>
<dt>haz2</dt>
<dd>(<code>numeric</code>) second summand (piecewise constant hazard).</dd>
<dt>pw1</dt>
<dd>(<code>numeric</code>) time intervals of first summand.</dd>
<dt>pw2</dt>
<dd>(<code>numeric</code>) time intervals of second summand.</dd></dl>

Arguments

Sum of Two Piecewise Constant Hazards — getSumPCW

<dl>

<dt>haz1</dt>
<dd>(<code>numeric</code>) first summand (piecewise constant hazard).</dd>


<dt>haz2</dt>
<dd>(<code>numeric</code>) second summand (piecewise constant hazard).</dd>


<dt>pw1</dt>
<dd>(<code>numeric</code>) time intervals of first summand.</dd>


<dt>pw2</dt>
<dd>(<code>numeric</code>) time intervals of second summand.</dd>

</dl>

getSumPCW: Sum of Two Piecewise Constant Hazards

Description

Usage

Value

Arguments

Examples