getWaitTimeSum

This returns event times with a distribution resulting from the sum of two Weibull distributed random variables
using the inversion method.

Based on the illness-death model a large number of clinical
trials with oncology endpoints progression-free survival (PFS) and
overall survival (OS) can be simulated, see Meller, Beyersmann and
Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows
for random and event-driven censoring, an arbitrary number of
treatment arms, staggered study entry and drop-out. Exponentially,
Weibull and piecewise exponentially distributed survival times can be
generated. The correlation between PFS and OS can be calculated.

Alexandra Erdmann

simIDM

Simulating Oncology Trials using an Illness-Death Model

Kaspar Rufibach

Holger Löwe

Daniel Sabanés Bové

F. Hoffmann-La Roche AG 

University of Ulm 

getWaitTimeSum function

<dl><dt>U</dt>
<dd>(<code>numeric</code>) uniformly distributed random variables.</dd>
<dt>haz1</dt>
<dd>(positive <code>number</code>) first summand (constant hazard).</dd>
<dt>haz2</dt>
<dd>(positive <code>number</code>) second summand (constant hazard).</dd>
<dt>p1</dt>
<dd>(positive <code>number</code>) rate parameter of Weibull distribution for <code>haz1</code>.</dd>
<dt>p2</dt>
<dd>(positive <code>number</code>) rate parameter of Weibull distribution for <code>haz2</code>.</dd>
<dt>entry</dt>
<dd>(<code>numeric</code>) the entry times in the current state.</dd></dl>

Arguments

Event Times Distributed as Sum of Weibull — getWaitTimeSum

<dl>

<dt>U</dt>
<dd>(<code>numeric</code>) uniformly distributed random variables.</dd>


<dt>haz1</dt>
<dd>(positive <code>number</code>) first summand (constant hazard).</dd>


<dt>haz2</dt>
<dd>(positive <code>number</code>) second summand (constant hazard).</dd>


<dt>p1</dt>
<dd>(positive <code>number</code>) rate parameter of Weibull distribution for <code>haz1</code>.</dd>


<dt>p2</dt>
<dd>(positive <code>number</code>) rate parameter of Weibull distribution for <code>haz2</code>.</dd>


<dt>entry</dt>
<dd>(<code>numeric</code>) the entry times in the current state.</dd>

</dl>

getWaitTimeSum: Event Times Distributed as Sum of Weibull

Description

Usage

Value

Arguments

Examples