integrateVector

internal

Based on the illness-death model a large number of clinical
trials with oncology endpoints progression-free survival (PFS) and
overall survival (OS) can be simulated, see Meller, Beyersmann and
Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows
for random and event-driven censoring, an arbitrary number of
treatment arms, staggered study entry and drop-out. Exponentially,
Weibull and piecewise exponentially distributed survival times can be
generated. The correlation between PFS and OS can be calculated.

Alexandra Erdmann

simIDM

Simulating Oncology Trials using an Illness-Death Model

Kaspar Rufibach

Holger Löwe

Daniel Sabanés Bové

F. Hoffmann-La Roche AG 

University of Ulm 

integrateVector function

<dl><dt>integrand</dt>
<dd>(<code>function</code>) to be integrated.</dd>
<dt>upper</dt>
<dd>(<code>numeric</code>) upper limits of integration.</dd>
<dt>...</dt>
<dd>additional arguments to be passed to <code>integrand</code>.</dd></dl>

Arguments

Helper for Efficient Integration — integrateVector

<dl>

<dt>integrand</dt>
<dd>(<code>function</code>) to be integrated.</dd>


<dt>upper</dt>
<dd>(<code>numeric</code>) upper limits of integration.</dd>


<dt>...</dt>
<dd>additional arguments to be passed to <code>integrand</code>.</dd>

</dl>

Helper for Efficient Integration

integrateVector: Helper for Efficient Integration

Description

Usage

Value

Arguments