generateClinicalTrialData
A function to generate some clinical trial data according the joint
model of response and survival for simulations
Reset the design object so that counts and results are zeroed out
Perform an interim look in a seamless Phase II-III clinical trial
A utility function to compute the hessian of the generalized (conditional)
partial likelihood ratio statistic
Given a design object, interim data and the current calendar time,
conduct the interim analysis for the time
Generate a seamless Phase II-III design object given some the true
parameters and clinical trial parameters
Given interim data, compute the response end-point summary
Compute the estimate of the variance of the generalized
likelihood ratio statistic at time \(t\)
Compute the modified Haybittle-Peto boundary
Compute the modified Haybittle-Peto boundary for the final look
sp23design: A package for the design, exploration and execution of seamless Phase
II-II clinical trials
Computes the constrained response log-likelihood (on the alternative)
Explore a specified design by simulation
A convenience function to reduce dimension by solving for one variable
\(c\) in terms of others \(a\), \(b\), \(d\)
Compute the response log-likelihood
Analyses the results of running a design. If a trial history, such as
the result of the function executeSP23Design Given the estimates of the \(\pi\) and \(\theta\), compute \(d\).
Computes the survival log-likelihood
Computes the constrained survival log-likelihood
Generate interim data for a clinical trial from a data set.