# spass v1.2

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## Study Planning and Adaptation of Sample Size

Sample size estimation and blinded sample size reestimation in Adaptive Study Design.

## Functions in spass

 Name Description sandwich2 Generate Time Series with Negative Binomial Distribution and Autoregressive Correlation Structure of Order One: NB-INAR(1) sim.bssr.gee.1subgroup Simulation of a longitudinal one subgroup design with internal pilot Study sim.bssr.1subgroup Simulation of a One Subgroup Design with Internal Pilot Study summary.bssrest Summarizing Blinded Sample Size Reestimation get.groups Generate Time Series with Negative Binomial Distribution and Multivariate Gamma Frailty with Autoregressive Correlation Structure of Order One with Trend n.1subgroup Sample Size Calculation for a One Subgroup Design n.gee.1subgroup Sample Size estimation for longitudinal GEE models n.nb.gf Sample Size Calculation for Comparing Two Groups when observing Longitudinal Count Data with marginal Negative Binomial Distribution and underlying Gamma Frailty with Autoregressive Correlation Structure of Order One test.nb.inar1 Testing Hypotheses in NB-INAR(1) model bssr.1subgroup Blinded Sample Size Recalculation for a One Subgroup Design n.nb.inar1 Sample Size Calculation for Comparing Two Groups when observing Longitudinal Count Data with marginal Negative Binomial Distribution and Autoregressive Correlation Structure of Order One: NB-INAR(1) r.1subgroup Generate dataset of normal distributed observations in a one subgroup design bssr.nb.gf Blinded Sample Size Reestimation for Longitudinal Count Data with marginal Negative Binomial Distribution and underlying Gamma Frailty with Autoregressive Correlation Structure of Order One bssr.nb.inar1 Blinded Sample Size Reestimation for Longitudinal Count Data using the NB-INAR(1) Model bssr.gee.1subgroup Blinded Sample Size Recalculation for longitudinal data in a One Subgroup Design r.gee.1subgroup Generate dataset of normal distributed repeated observations in a one subgroup design rnbinom.gf Generate Time Series with Negative Binomial Distribution and Multivariate Gamma Frailty with Autoregressive Correlation Structure of Order One summary.ssest Summarizing Initial Sample Size Estimates test.nb.gf Testing Hypotheses in Gamma Frailty models estimcov Estimation of simulation parameters fit.nb.inar1 Fitting Longitudinal Data with Negative Binomial Marginal Distribution and Autoregressive Correlation Structure of Order One: NB-INAR(1) gen_cov_cor Generation of a covariance or a correlation matrix fit.nb.gf Fitting Longitudinal Data from a Gamma Frailty Model with Frailty of Autoregressive Correlation Structure of Order One sandwich Calculate the robust covariance estimator for GEE given an rnbinom.inar1 Generate Time Series with Negative Binomial Distribution and Autoregressive Correlation Structure of Order One: NB-INAR(1) No Results!