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speff2trial (version 1.0.0)

ACTG175: AIDS Clinical Trials Group Study 175

Description

ACTG 175 was a randomized clinical trial to compare monotherapy with zidovudine or didanosine with combination therapy with zidovudine and didanosine or zidovudine and zalcitabine in adults infected with the human immunodeficiency virus type I whose CD4 cell counts were between 200 and 500 per cubic millimeter.

Usage

data(ACTG175)

Arguments

Details

There are two treatment arms in the data set, zidovudine monotherapy and the mixture of all other study therapies. The data set includes the following post-randomization covariates: CD4 and CD8 cell count at 20$\pm$5 weeks and the indicator of whether or not the patient was taken off-treatment before 96$\pm$5 weeks.

References

Hammer SM, et al. (1996), "A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter.", New England Journal of Medicine, 335:1081--1090.