prophr

Computes the event probability in the experimental group based on the event
probability in the control group and a specified hazard ratio, assuming
proportional hazards.

Functions for sample size estimation and simulation in clinical
trials. Includes methods for selecting the best group using the
Indifference-zone approach, as well as designs for non-inferiority,
equivalence, and negative binomial models. For the sample size calculation
for non-inferiority of vaccines, the approach is based on Fleming, Powers,
and Huang (2021) <doi:10.1177/1740774520988244>. The Indifference-zone
approach is based on Sobel and Huyett (1957) <doi:10.1002/j.1538-7305.1957.tb02411.x> and
Bechhofer, Santner, and Goldsman (1995, ISBN:978-0-471-57427-9).

Aponte John

ssutil

Sample Size Calculation Tools

John J. Aponte

Chris Gast

prophr function

<dl><dt>p0</dt>
<dd>Numeric scalar. Probability of an event in the control group (between 0 and 1).</dd>
<dt>hr</dt>
<dd>Numeric scalar. Hazard ratio (must be &gt; 0).</dd></dl>

Arguments

Calculate Event Probability in the Experimental Group Given a Hazard Ratio — prophr

<dl>

<dt>p0</dt>
<dd>Numeric scalar. Probability of an event in the control group (between 0 and 1).</dd>


<dt>hr</dt>
<dd>Numeric scalar. Hazard ratio (must be &gt; 0).</dd>

</dl>

prophr: Calculate Event Probability in the Experimental Group Given a Hazard Ratio

Description

Usage

Value

Arguments

Details

Examples