opchars.tite

Internal workhorse function to calculate operating characteristics for a given stopping rule and toxicity probability

Provides functions for creating, displaying, and evaluating stopping rules for safety monitoring in clinical studies.

Michael Martens

stoppingrule

Create and Evaluate Stopping Rules for Safety Monitoring

Qinghua Lian

opchars.tite function

<dl><dt>rule</dt>
<dd>A <code>rule.tite</code> object with the safety stopping rule for evaluation</dd>
<dt>p</dt>
<dd>Vector of cumulative incidence probabilities at time <code>tau</code> for all causes (length 1 for survival, 2 for competing risks)</dd>
<dt>tau</dt>
<dd>Length of observation period</dd>
<dt>MC</dt>
<dd>Number of Monte Carlo replicated datasets to simulate</dd>
<dt>A</dt>
<dd>Length of accrual period</dd>
<dt>family</dt>
<dd>Event time distribution, choices including Weibull distribution ('weibull') and power family ('power')</dd>
<dt>s</dt>
<dd>Shape parameter for Weibull distribution or power parameter for power family</dd></dl>

Arguments

Operating Characteristics Function (TITE Method) — opchars.tite

<dl>

<dt>rule</dt>
<dd>A <code>rule.tite</code> object with the safety stopping rule for evaluation</dd>


<dt>p</dt>
<dd>Vector of cumulative incidence probabilities at time <code>tau</code> for all causes (length 1 for survival, 2 for competing risks)</dd>


<dt>tau</dt>
<dd>Length of observation period</dd>


<dt>MC</dt>
<dd>Number of Monte Carlo replicated datasets to simulate</dd>


<dt>A</dt>
<dd>Length of accrual period</dd>


<dt>family</dt>
<dd>Event time distribution, choices including Weibull distribution ('weibull') and power family ('power')</dd>


<dt>s</dt>
<dd>Shape parameter for Weibull distribution or power parameter for power family</dd>

</dl>

opchars.tite: Operating Characteristics Function (TITE Method)

Description

Usage

Value

Arguments