sim_tite_data

Simulate time-to-event data for safety monitoring under Weibull distribution or power family (TITE Method)

Provides functions for creating, displaying, and evaluating stopping rules for safety monitoring in clinical studies.

Michael Martens

stoppingrule

Create and Evaluate Stopping Rules for Safety Monitoring

Qinghua Lian

sim_tite_data function

<dl><dt>n</dt>
<dd>Sample size</dd>
<dt>p</dt>
<dd>Vector of cumulative incidence probabilities at time <code>tau</code> for all causes (length 1 for survival, 2 for competing risks)</dd>
<dt>tau</dt>
<dd>Length of observation period</dd>
<dt>A</dt>
<dd>Length of accrual period</dd>
<dt>family</dt>
<dd>Event time distribution, choices including Weibull distribution ('weibull'), or power family ('power')</dd>
<dt>s</dt>
<dd>Shape parameter for Weibull distribution or power parameter for power family</dd></dl>

Arguments

<ul>
<li><code>sim_tite_data()</code>: function to simulate time-to-event data from either Weibull or power family distribution for evaluating safety
monitoring rules. A random sample of size <code>n</code> is generated from a Weibull
distribution with shape parameter <code>s</code> or power family distribution with power parameter <code>s</code> to attain a toxicity rate matching the first element of <code>p</code> at
event time <code>tau</code>. Enrollment times are also simulated over an accrual period
of duration <code>A</code> under a uniform (0,<code>A</code>) distribution.</li>
</ul>

Functions

Simulate time-to-event data for safety monitoring under Weibull distribution or power family (TITE Method) — sim_tite_data

<dl>

<dt>n</dt>
<dd>Sample size</dd>


<dt>p</dt>
<dd>Vector of cumulative incidence probabilities at time <code>tau</code> for all causes (length 1 for survival, 2 for competing risks)</dd>


<dt>tau</dt>
<dd>Length of observation period</dd>


<dt>A</dt>
<dd>Length of accrual period</dd>


<dt>family</dt>
<dd>Event time distribution, choices including Weibull distribution ('weibull'), or power family ('power')</dd>


<dt>s</dt>
<dd>Shape parameter for Weibull distribution or power parameter for power family</dd>

</dl>

sim_tite_data: Simulate time-to-event data for safety monitoring under Weibull distribution or power family (TITE Method)

Description

Usage

Value

Arguments

Functions