simdata_weibull

Internal function to simulate survival data from Weibull distribution for evaluating safety
monitoring rules. A random sample of size <code>n</code> is generated from a Weibull
distribution with shape parameter <code>s</code> to attain a toxicity rate of <code>p</code> at
survival time <code>tau</code>. Enrollment times are also simulated over an accrual period
of duration <code>A</code> under a uniform (0,<code>A</code>) distribution.

Provides functions for creating, displaying, and evaluating stopping rules for safety monitoring in clinical studies.

Michael Martens

stoppingrule

Create and Evaluate Stopping Rules for Safety Monitoring

Qinghua Lian

simdata_weibull function

<dl><dt>n</dt>
<dd>Maximum sample size for safety monitoring</dd>
<dt>p</dt>
<dd>The probability of a toxicity occurring in <code>tau</code> units of time under the null hypothesis</dd>
<dt>tau</dt>
<dd>Length of observation period</dd>
<dt>A</dt>
<dd>Length of accrual period</dd>
<dt>s</dt>
<dd>Shape parameter for the Weibull distribution; default value is 1
(exponential distribution)</dd></dl>

Arguments

Simulate survival data for safety monitoring under Weibull distribution — simdata_weibull

<dl>

<dt>n</dt>
<dd>Maximum sample size for safety monitoring</dd>


<dt>p</dt>
<dd>The probability of a toxicity occurring in <code>tau</code> units of time under the null hypothesis</dd>


<dt>tau</dt>
<dd>Length of observation period</dd>


<dt>A</dt>
<dd>Length of accrual period</dd>


<dt>s</dt>
<dd>Shape parameter for the Weibull distribution; default value is 1
(exponential distribution)</dd>

</dl>

simdata_weibull: Simulate survival data for safety monitoring under Weibull distribution

Description

Usage

Value

Arguments