SMCtest: This function performs stratified Max-Combo test.

Description

This function performs stratified Max-Combo test.

Usage

SMCtest(
  time,
  event,
  group,
  stratum,
  alternative = c("two.sided", "less", "greater"),
  rho = c(0, 1, 1, 0),
  gamma = c(0, 0, 1, 1)
)

Value

A list with components:

z.list: a vector of z values calculated from all startified weighted log-rank tests under stratification method 1.
z.max: the z value that is the furthest away from 0 under stratification method 1.
cov: the covariance matrix of different startified weighted log-rank tests under stratification method 1.
pval: p-value of desired alternative test under stratification method 1.
z.list2: a vector of z values calculated from all startified weighted log-rank tests under stratification method 2.
z.max2: the z value that is the furthest away from 0 under stratification method 2.
cov2: the covariance matrix of different startified weighted log-rank tests under stratification method 2.
pval2: p-value of desired alternative test under stratification method 2.
z.list3: a vector of z values calculated from all startified weighted log-rank tests under stratification method 3.
z.max3: the z value that is the furthest away from 0 under stratification method 3.
cov3: the covariance matrix of different startified weighted log-rank tests under stratification method 3.
pval3: p-value of desired alternative test under stratification method 3.

Arguments

time: a vector of event or censored times.
event: a vector with entries 0 or 1, indicating event occurrence (1) or time being censored (0).
group: a vector indicating treatment groups.
stratum: a vector of stratification factor.
alternative: choose from "two.sided", "less" or "greater" to determine which type of tests to conduct and calculate the corresponding p-values.
rho: a vector indicating different values of rho in Fleming-Harrington weight.
gamma: a vector indicating different values of gamma in Fleming-Harrington weight.

References

Magirr, D. and Jiménez, J. (2023). Stratified modestly-weighted log-rank tests in settings with an anticipated delayed separation of survival curves. Biometrical Journal., 2023;65:2200126 tools:::Rd_expr_doi("10.1002/bimj.202200126")

Examples

Run this code

data(sim_data)
##load survival data
time <- sim_data$event_time
event <- sim_data$event_status
group <- sim_data$group
stratum <- sim_data$strata

##perform stratified max-combo test
SMCtest(time,event,group,stratum,alternative="two.sided",rho=c(0,1,1,0),gamma=c(0,0,1,1))