sim_data

<p>Simulated survival data for demonstrating the usage of WLRtest and SMCtest.</p>

datasets

Non-proportional hazard (NPH) is commonly observed in immuno-oncology studies, where the survival curves of the treatment and control groups show delayed separation. To properly account for NPH, several statistical methods have been developed. One such method is Max-Combo test, which is a straightforward and flexible hypothesis testing method that can simultaneously test for constant, early, middle, and late treatment effects. However, the majority of the Max-Combo test performed in clinical studies are unstratified, ignoring the important prognostic stratification factors. To fill this gap, we have developed an R package for stratified Max-Combo testing that accounts for stratified baseline factors. Our package explores various methods for calculating combined test statistics, estimating joint distributions, and determining the p-values.

Yuwen Liu

strata.MaxCombo

Stratified Max-Combo Test

Yumeng Wang

sim_data function

<p>The data file consists of four components: event_time, event_status, group and strata. Data contains different event_times, two event_status (0: censored and 1: event), two groups (control and experimental) and two stratum (first and second).</p>

sim_data: simulated survival data with two stratum

Description

Usage

Arguments

Format

See Also