The data frame hepatitis is obtained by digitizing the published
Kaplan-Meier curves in Nguyen-Khac et al. (2011). The method of digitizing is described in
Guyot et al. (2012).
See intELtest for the application.
hepatitisThe hepatitis is a data frame with 174 observations of 3 variables,
and has the following columns:
time the observed survival and censoring times
censor the censoring indicator
group the grouping variable
P. Guyot, A. E. Ades, M. J. N. M. Ouwens, and N. J. Welton, "Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves," BMC Medical Research Methodology, 12(1):9. http://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-12-9
Nguyen-Khac et al., "Glucocorticoids plus N-Acetylcysteine in Severe Alcoholic Hepatitis," The New England Journal of Medicine, Vol. 365, No. 19, pp. 1781-1789 (2011). http://www.nejm.org/doi/full/10.1056/NEJMoa1101214#t=article
P. Guyot, A. E. Ades, M. J. N. M. Ouwens, and N. J. Welton, "Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves," BMC Medical Research Methodology, 12(1):9. http://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-12-9