Split data into the training and testing sets for meta analysis.
Usage
det.set.meta(i, j, geno.files, surv.data, method)
Arguments
i
A vector of character strings consisting of the names of the expression files used for the training set.
j
A character string specifying the name of the expression file used for the testing set.
geno.files
A vector of character strings consisting of the names of the expression files.
surv.data
A list of two vectors, survival time and censoring status. In the censoring status vector, 1 = event occurred, 0 = censored.
method
A character string specifying the feature selection method: "none" for top-100 ranking or one of the adjusting methods specified by the p.adjust function
Value
None.
Details
In top-ranking, genes are selected based on univariate Cox P-value ranking using
the coxph function in the R survival package. In this feature selection method,
the genes are ranked based on their likelihood ratio P-value and the top-100 ranked genes with the smallest P-values are retained as the gene signature.
The p.adjust function in the R stats package is used and all adjusted p-values not greater than 0.05 are retained if method != "none".