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sybil (version 1.1.2)

sysBiolAlg_fba-class: Class "sysBiolAlg_fba"

Description

The class sysBiolAlg_fba holds an object of class optObj which is generated to meet the requirements of the FBA algorithm.

Arguments

encoding

utf8

Objects from the Class

Objects can be created by calls of the form sysBiolAlg(model, algorithm = "fba", ...). Arguments to ... which are passed to method initialize of class sysBiolAlg_fba are described in the Details section.

Extends

Class "sysBiolAlg", directly.

Methods

No methods defined with class "sysBiolAlg_fba" in the signature.

Details

The initialize method has the following arguments: [object Object],[object Object],[object Object],[object Object]

The problem object is built to be capable to perform flux balance analysis (FBA) with a given model, which is basically the solution of a linear programming problem $$\begin{array}{rll} \max & \mbox{\boldmath$c$\unboldmath}^{\mathrm{T}} \mbox{\boldmath$v$\unboldmath} \[1ex] \mathrm{s.\,t.} & \mbox{\boldmath$Sv$\unboldmath} = 0 \[1ex] & \alpha_i \leq v_i \leq \beta_i & \quad \forall i \in {1, \ldots, n} \[1ex] \end{array}$$ with $\bold{S}$ beeing the stoichiometric matrix, $\alpha_i$ and $\beta_i$ beeing the lower and upper bounds for flux (variable) $i$ respectively. The total number of variables of the optimization problem is denoted by $n$. The solution of the optimization is a flux distribution maximizing the objective function $\mbox{\boldmath$c$\unboldmath}^{\mathrm{T}} \mbox{\boldmath$v$\unboldmath}$ under the a given environment and the assumption of steady state. The optimization can be executed by using optimizeProb.

References

Edwards, J. S., Covert, M and Palsson, B. Ø. (2002) Metabolic modelling of microbes: the flux-balance approach. Environ Microbiol 4, 133--140. Edwards, J. S., Ibarra, R. U. and Palsson, B. Ø. (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 19, 125--130.

See Also

Constructor function sysBiolAlg and superclass sysBiolAlg.

Examples

Run this code
showClass("sysBiolAlg_fba")

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