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tacmagic (version 0.3.1)

Positron Emission Tomography Time-Activity Curve Analysis

Description

To facilitate the analysis of positron emission tomography (PET) time activity curve (TAC) data, and to encourage open science and replicability, this package supports data loading and analysis of multiple TAC file formats. Functions are available to analyze loaded TAC data for individual participants or in batches. Major functionality includes weighted TAC merging by region of interest (ROI), calculating models including standardized uptake value ratio (SUVR) and distribution volume ratio (DVR, Logan et al. 1996 ), basic plotting functions and calculation of cut-off values (Aizenstein et al. 2008 ). Please see the walkthrough vignette for a detailed overview of 'tacmagic' functions.

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Install

install.packages('tacmagic')

Monthly Downloads

183

Version

0.3.1

License

GPL-3

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Repository

https://github.com/ropensci/tacmagic

Maintainer

Eric Brown

Last Published

December 9th, 2020

Functions in tacmagic (0.3.1)

Fake DVR data for vignette and package testing

Calculate one or more models for a batch of participants

Obtain values from voistat files (using load_voistat() for a batch.

Distribution volume ratio (DVR) for one or more ROIs

Convert radioactivity units

Cutoff value calculation using method described in Aizenstein et al. 2008

Load (+/- merge) ROIs for batch of participants

Creates a tac object from a data.frame

Return a list of merged ROIs made up of atomic ROIs in the Hammer's atlas.

Return a list of merged ROIs made up of the atomic ROIs in the Hammer's atlas.

Reads PMOD .voistat files and optionally merges volume-weighted ROIs

Loads TAC from file for use by other functions (default is PMOD .tac format)

Calculate SUVRs for regions of interest with AUC from mid-frame times

Calculate weighted time-activity curves for specified regions of interest

Calculate weighted SUVRs for specified regions of interest

Dichotomize participants based on ROI cutoff values

Calculate average SUV over time window, or maximum SUV

Plots time activity curves from 1 or 2 participants or groups.

Subset PMOD tacs with or without PVC

Save a tac object as a .tac file

tacmagic: PET Analysis in R

Calculate SUV from TAC

Non-invasive reference Logan plot

Loads ROI volumes from file for use by other functions

DVR_all_ref_Logan

Non-invasive reference Logan method for all ROIs in tac data

Return a list of merged ROIs made up of the atomic ROIs in the AAL atlas. The groupings for major lobes are as described in the PMOD documentation.

Non-invasive reference Logan method

Return a list of larger ROIs made up of the ROIs in the Hammer's atlas.