apply_targetfn

Function to apply any specified target function to a PK-PD model
and TCI algorithm.

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

apply_targetfn function

<dl><dt>lp</dt>
<dd>Logged parameter values</dd>
<dt>tm</dt>
<dd>Time values to evaluate</dd>
<dt>targetfn</dt>
<dd>Target function</dd>
<dt>prior_pk</dt>
<dd>Prior PK point estimates</dd>
<dt>prior_pd</dt>
<dd>Prior PD point estimates</dd>
<dt>pkmod</dt>
<dd>PK model to evaluate</dd>
<dt>pdmod</dt>
<dd>PD model to evaluate</dd>
<dt>pdinv</dt>
<dd>Inverse PD model</dd>
<dt>...</dt>
<dd>Additional arguments passed on to tci_pd</dd></dl>

Arguments

Apply target function to a PK-PD model — apply_targetfn

<dl>

<dt>lp</dt>
<dd>Logged parameter values</dd>


<dt>tm</dt>
<dd>Time values to evaluate</dd>


<dt>targetfn</dt>
<dd>Target function</dd>


<dt>prior_pk</dt>
<dd>Prior PK point estimates</dd>


<dt>prior_pd</dt>
<dd>Prior PD point estimates</dd>


<dt>pkmod</dt>
<dd>PK model to evaluate</dd>


<dt>pdmod</dt>
<dd>PD model to evaluate</dd>


<dt>pdinv</dt>
<dd>Inverse PD model</dd>


<dt>...</dt>
<dd>Additional arguments passed on to tci_pd</dd>

</dl>

apply_targetfn: Apply target function to a PK-PD model

Description

Usage

Value

Arguments