eleveld_vcov

Generate the variance-covariance matrix for Eleveld PK-PD model for an observation
via Monte Carlo sampling.

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

eleveld_vcov function

<dl><dt>dat</dt>
<dd>Data frame of observed patient covariates</dd>
<dt>N</dt>
<dd>Number of Monte Carlo samples</dd>
<dt>rates</dt>
<dd>Logical. Should rate constants be calculated</dd>
<dt>varnames</dt>
<dd>Column names of variables used to calculate variance-covariance matrix</dd></dl>

Arguments

Generate variance-covariance matrix for Eleveld PK-PD model — eleveld_vcov

<dl>

<dt>dat</dt>
<dd>Data frame of observed patient covariates</dd>


<dt>N</dt>
<dd>Number of Monte Carlo samples</dd>


<dt>rates</dt>
<dd>Logical. Should rate constants be calculated</dd>


<dt>varnames</dt>
<dd>Column names of variables used to calculate variance-covariance matrix</dd>

</dl>

eleveld_vcov: Generate variance-covariance matrix for Eleveld PK-PD model

Description

Usage

Value

Arguments