log_posterior_neg

Function to evaluate the negative log posterior given a set of logged parameter values and observed BIS values.

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

log_posterior_neg function

<dl><dt>lpr</dt>
<dd>logged PK-PD-error parameter values</dd>
<dt>dat</dt>
<dd>data frame with columns corresponding to observed time and PD response values.</dd>
<dt>mu</dt>
<dd>Mean of prior distribution.</dd>
<dt>sig</dt>
<dd>Variance-covariance matrix of prior distribution.</dd>
<dt>...</dt>
<dd>Arguments passed on to log-likelihood.</dd></dl>

Arguments

Function to evaluate the negative log posterior given a set of logged parameter values and observed BIS values. — log_posterior_neg

<dl>

<dt>lpr</dt>
<dd>logged PK-PD-error parameter values</dd>


<dt>dat</dt>
<dd>data frame with columns corresponding to observed time and PD response values.</dd>


<dt>mu</dt>
<dd>Mean of prior distribution.</dd>


<dt>sig</dt>
<dd>Variance-covariance matrix of prior distribution.</dd>


<dt>...</dt>
<dd>Arguments passed on to log-likelihood.</dd>

</dl>

log_posterior_neg: Function to evaluate the negative log posterior given a set of logged parameter values and observed BIS values.

Description

Usage

Value

Arguments