marsh_poppk

Takes in a vector of patient weights and returns a data frame of patient PK-PD parameters.
KE0 parameter set to 1.2 in accordance with recommendations
from Absalom et al., 2009 "Pharmacokinetic models for propofol- Defining and
illuminating the devil in the detail"

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

marsh_poppk function

<dl><dt>df</dt>
<dd>data frame with column titled "TBM" giving patient total body
mass in kg.</dd>
<dt>rate</dt>
<dd>Logical. Should elimination rate constants be returned instead
of clearance parameters.</dd></dl>

Arguments

------------------------------------------------------------------------------------
Population PK and PK-PD functions --------------------------------------------------
------------------------------------------------------------------------------------
Marsh population PK model. — marsh_poppk

<dl>

<dt>df</dt>
<dd>data frame with column titled "TBM" giving patient total body
mass in kg.</dd>


<dt>rate</dt>
<dd>Logical. Should elimination rate constants be returned instead
of clearance parameters.</dd>

</dl>

------------------------------------------------------------------------------------
Population PK and PK-PD functions --------------------------------------------------
------------------------------------------------------------------------------------
Marsh population PK model.

marsh_poppk: ------------------------------------------------------------------------------------ Population PK and PK-PD functions -------------------------------------------------- ------------------------------------------------------------------------------------ Marsh population PK model.

Description

Usage

Value

Arguments