pkmod3cpt

Three compartment IV infusion with first-order elimination.

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

pkmod3cpt function

<dl><dt>tm</dt>
<dd>Vector of times to evaluate the PK function at</dd>
<dt>kR</dt>
<dd>Infusion rate (e.g. ml/min).</dd>
<dt>pars</dt>
<dd>Named vector of parameters with names ('K10','K12','K21','V1','V2') or ('CL','Q','V1','V2').</dd>
<dt>init</dt>
<dd>Initial concentration. Defaults to 0 in all compartments.</dd>
<dt>inittm</dt>
<dd>Time of initiation of infusion. Defaults to 0.</dd>
<dt>k20</dt>
<dd>Elimination rate constant for second compartment. Defaults to 0.</dd>
<dt>k30</dt>
<dd>Elimination rate constant for second compartment. Defaults to 0.</dd></dl>

Arguments

Three compartment IV infusion with first-order elimination. — pkmod3cpt

<dl>

<dt>tm</dt>
<dd>Vector of times to evaluate the PK function at</dd>


<dt>kR</dt>
<dd>Infusion rate (e.g. ml/min).</dd>


<dt>pars</dt>
<dd>Named vector of parameters with names ('K10','K12','K21','V1','V2') or ('CL','Q','V1','V2').</dd>


<dt>init</dt>
<dd>Initial concentration. Defaults to 0 in all compartments.</dd>


<dt>inittm</dt>
<dd>Time of initiation of infusion. Defaults to 0.</dd>


<dt>k20</dt>
<dd>Elimination rate constant for second compartment. Defaults to 0.</dd>


<dt>k30</dt>
<dd>Elimination rate constant for second compartment. Defaults to 0.</dd>

</dl>

pkmod3cpt: Three compartment IV infusion with first-order elimination.

Description

Usage

Value

Arguments

Examples