restrict_sigmoid

Function to place restriction on gamma and E50 parameters of target sigmoid
such that it passes through point (tfinal, BISfinal+eps)

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

restrict_sigmoid function

<dl><dt>t50</dt>
<dd>parameter of Emax model</dd>
<dt>tfinal</dt>
<dd>end of the induction period</dd>
<dt>eps</dt>
<dd>distance between BISfinal and the target function at tfinal</dd>
<dt>BIS0</dt>
<dd>starting BIS value</dd>
<dt>BISfinal</dt>
<dd>asymptote of Emax model</dd></dl>

Arguments

Restrict target sigmoid values — restrict_sigmoid

<dl>

<dt>t50</dt>
<dd>parameter of Emax model</dd>


<dt>tfinal</dt>
<dd>end of the induction period</dd>


<dt>eps</dt>
<dd>distance between BISfinal and the target function at tfinal</dd>


<dt>BIS0</dt>
<dd>starting BIS value</dd>


<dt>BISfinal</dt>
<dd>asymptote of Emax model</dd>

</dl>

restrict_sigmoid: Restrict target sigmoid values

Description

Usage

Value

Arguments

Examples