tci (version 0.2.0)

pkmod3cptm: Solution to three-compartment IV model with effect-site

Description

3 compartment IV infusion with first-order absorption between compartments and with an additional effect-site compartment. The analytical solutions implemented in this function are provided in "ADVAN-style analytical solutions for common pharmacokinetic models" by Abuhelwa et al. 2015.

Usage

pkmod3cptm(tm, kR, pars, init = c(0, 0, 0, 0))

Value

Numeric matrix of concentrations for a constant infusion rate

Arguments

tm

Vector of times to evaluate the PK function at

kR

Infusion rate (e.g. ml/min).

pars

Named vector of parameters with names (k10,k12,k21,k13,k31,v1,v2,v3,ke0)

init

Initial concentration

Details

This function takes in arguments for each of the absorption and elimination rate constants of a three-compartment model as well as initial concentrations, c0. ke0 gives the rate of elimination from the effect-site compartment into the central compartment (i.e. k41). The rate of absorption into the effect-site compartment is set at 1/10,000 the value of ke0. The function returns a set of functions that calculate the concentration in each of the four compartments as a function of time.

Examples

pars_3cpt <- c(k10=1.5,k12=0.15,k21=0.09,k13=0.8,k31=0.8,v1=10,v2=15,v3=100,ke0=1)
pkmod3cptm(1,1,pars_3cpt)