pkmod_marsh

Evaluates the Marsh propofol model at patient covariates (total body mass) and
returns a `pkmod` object. KE0 parameter set to 1.2 in accordance with recommendations
from Absalom et al., 2009 "Pharmacokinetic models for propofol- Defining and
illuminating the devil in the detail."

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

pkmod_marsh function

<dl><dt>TBW</dt>
<dd>Weight (kg)</dd>
<dt>...</dt>
<dd>Arguments passed to `pkmod`</dd></dl>

Arguments

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Population PK and PK-PD functions -------------------------------------------
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Marsh population PK model for propofol — pkmod_marsh

<dl>

<dt>TBW</dt>
<dd>Weight (kg)</dd>


<dt>...</dt>
<dd>Arguments passed to `pkmod`</dd>

</dl>

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Population PK and PK-PD functions -------------------------------------------
-----------------------------------------------------------------------------
Marsh population PK model for propofol

pkmod_marsh: ----------------------------------------------------------------------------- Population PK and PK-PD functions ------------------------------------------- ----------------------------------------------------------------------------- Marsh population PK model for propofol

Description

Usage

Value

Arguments

Examples