tci (version 0.2.0)

pkmod_minto: Minto population PK model for remifentanil

Description

Evaluate Minto population PK model at patient covariate values. Published in Minto et al. (1997). "Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development." Anesthesiology 86:10-23 doi: https://doi.org/10.1097/00000542-199701000-00004. Residual error standard deviations are taken from Eleveld et al. (2017). "An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics." Anesthesiology Vol. 126, 1005–1018 doi: https://doi.org/10.1097/ALN.0000000000001634.

Usage

pkmod_minto(
  AGE,
  HGT = NULL,
  TBW = NULL,
  MALE = NULL,
  LBM = NULL,
  PD = TRUE,
  ...
)

Value

`pkmod` object with Schnider population PK parameters

Arguments

AGE

Age (years)

HGT

Height (cm). Used to calculate LBM if LBM is not provided.

TBW

Weight (kg). Used to calculate LBM if LBM is not provided.

MALE

Logical. Used to calculate LBM if LBM is not provided.

LBM

Lean body mass (kg). Can be provided instead of TBW, HGT, and MALE

PD

Logical. Should PD parameters be returned in addition to PK parameters.

...

Arguments passed to `pkmod`

Examples

pkmod_minto(AGE = 40,HGT=170,LBM = 43.9)
pkmod_minto(AGE = 40,HGT=170,TBW=50,MALE=TRUE)