pkmod_schnider

Evaluate Schnider population PK model at patient covariate values.
Published in Schnider et al. (1998). "The influence of method of administration
and covariates on the pharmacokinetics of propofol in adult volunteers."
Anesthesiology 88 (5):1170-82.

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

pkmod_schnider function

<dl><dt>AGE</dt>
<dd>Age (years)</dd>
<dt>HGT</dt>
<dd>Height (cm)</dd>
<dt>LBM</dt>
<dd>Lean body mass (kg). Can be provided instead of TBW, and MALE</dd>
<dt>TBW</dt>
<dd>Weight (kg). Used to calculate LBM if LBM is not provided.</dd>
<dt>MALE</dt>
<dd>Logical. Used to calculate LBM if LBM is not provided.</dd>
<dt>...</dt>
<dd>Arguments passed to `pkmod`</dd></dl>

Arguments

Schnider population PK model for propofol — pkmod_schnider

<dl>

<dt>AGE</dt>
<dd>Age (years)</dd>


<dt>HGT</dt>
<dd>Height (cm)</dd>


<dt>LBM</dt>
<dd>Lean body mass (kg). Can be provided instead of TBW, and MALE</dd>


<dt>TBW</dt>
<dd>Weight (kg). Used to calculate LBM if LBM is not provided.</dd>


<dt>MALE</dt>
<dd>Logical. Used to calculate LBM if LBM is not provided.</dd>


<dt>...</dt>
<dd>Arguments passed to `pkmod`</dd>

</dl>

pkmod_schnider: Schnider population PK model for propofol

Description

Usage

Value

Arguments

Examples