sample_pkmod

Sample parameters from a `pkmod` object

Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

Ryan Jarrett

Target Controlled Infusion (TCI)

sample_pkmod function

<dl><dt>pkmod</dt>
<dd>`pkmod` object with associated Omega matrix describing random effect variances</dd>
<dt>log_normal</dt>
<dd>Logical. Assumes random effects are log-normally distributed
and multiplicative if TRUE, additive and normally distributed if FALSE.</dd>
<dt>...</dt>
<dd>Arguments passed to update.pkmod</dd></dl>

Arguments

Sample parameters from a `pkmod` object — sample_pkmod

<dl>

<dt>pkmod</dt>
<dd>`pkmod` object with associated Omega matrix describing random effect variances</dd>


<dt>log_normal</dt>
<dd>Logical. Assumes random effects are log-normally distributed
and multiplicative if TRUE, additive and normally distributed if FALSE.</dd>


<dt>...</dt>
<dd>Arguments passed to update.pkmod</dd>

</dl>

sample_pkmod: Sample parameters from a `pkmod` object

Description

Usage

Value

Arguments

Examples