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TCI algorithm based on the algorithm described by Jacobs (1990).
tci_plasma(Ct, pkmod, dtm = 1/6, maxrt = 1200, ...)Numeric value
Target plasma concentration
PK model
Duration of the infusion
Maximum infusion rate. Defaults to 200 ml/min in reference to the maximum infusion rate of 1200 ml/h permitted by existing TCI pumps (e.g. Anestfusor TCI program).
Arguments passed on to update.pkmod.
# plasma targeting
my_mod <- pkmod(pars_pk = c(CL = 10, V1 = 10))
tci_plasma(Ct = 2, my_mod)
# update CL parameter
tci_plasma(Ct = 2, my_mod, pars_pk = c(CL = 15))
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