loggnls

\(f(x) = \frac{tp}{[(1 + 10^{(p*(ga-x))} )(1 + 10^{(q*(x-la))} )]}\)

The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.

Jason Brown

tcplfit2

A Concentration-Response Modeling Utility

Thomas Sheffield

Richard S Judson

Sarah E. Davidson

Zhihui Zhao

Madison Feshuk

Katie Paul Friedman

loggnls function

<dl><dt>ps</dt>
<dd>Vector of parameters: tp,ga,p,la,q,er (ga and la are in log10-scale)</dd>
<dt>x</dt>
<dd>Vector of concentrations (log10 units)</dd></dl>

Arguments

Log Gain-Loss Model — loggnls

<dl>

<dt>ps</dt>
<dd>Vector of parameters: tp,ga,p,la,q,er (ga and la are in log10-scale)</dd>


<dt>x</dt>
<dd>Vector of concentrations (log10 units)</dd>

</dl>

loggnls: Log Gain-Loss Model

Description

Usage

Value

Arguments

Examples