teal.modules.clinical (version 0.12.0)

tm_t_glm_counts: Teal Module: Regression Counts Summary

Description

Summarize results of a Poisson negative binomial regression that is result of a generalized linear model of one (e.g. arm) or more covariates.

Usage

tm_t_glm_counts(
  label = "Counts Module",
  dataname,
  parentname = ifelse(inherits(arm_var, "data_extract_spec"),
    teal.transform::datanames_input(arm_var), "ADSL"),
  aval_var = teal.transform::choices_selected(teal.transform::variable_choices(dataname,
    "AVAL"), "AVAL", fixed = TRUE),
  arm_var,
  strata_var,
  rate_mean_method = c("emmeans", "ppmeans"),
  distribution = c("negbin", "quasipoisson", "poisson"),
  offset_var,
  cov_var,
  arm_ref_comp = NULL,
  conf_level = teal.transform::choices_selected(c(0.95, 0.9, 0.8), 0.95, keep_order =
    TRUE),
  pre_output = NULL,
  post_output = NULL,
  basic_table_args = teal.widgets::basic_table_args(),
  transformators = list(),
  decorators = list()
)

Value

a teal_module object.

Arguments

label

(character)
menu item label of the module in the teal app.

dataname

(character)
analysis data used in teal module.

parentname

(character)
parent analysis data used in teal module, usually this refers to ADSL.

aval_var

(character)
name of the analysis value variable.

arm_var

(character)
variable names that can be used as arm_var.

strata_var

(character)
names of the variables for stratified analysis.

rate_mean_method

(character) method used to estimate the mean odds ratio. Either "emmeans" or "ppmeans" (as in summarize_glm_count()).

distribution

(character) value specifying the distribution used in the regression model (Poisson: "poisson", Quasi-Poisson: "quasipoisson", negative binomial: "negbin").

offset_var

(character) a name of the numeric variable to be used as an offset?

cov_var

(character)
names of the covariates variables.

arm_ref_comp

(list) optional,
if specified it must be a named list with each element corresponding to an arm variable in ADSL and the element must be another list (possibly with delayed teal.transform::variable_choices() or delayed teal.transform::value_choices() with the elements named ref and comp that the defined the default reference and comparison arms when the arm variable is changed.

conf_level

(teal.transform::choices_selected())
object with all available choices and pre-selected option for confidence level, each within range of (0, 1).

pre_output

(shiny.tag) optional,
with text placed before the output to put the output into context. For example a title.

post_output

(shiny.tag) optional,
with text placed after the output to put the output into context. For example the shiny::helpText() elements are useful.

basic_table_args

(basic_table_args) optional
object created by teal.widgets::basic_table_args() with settings for the module table. The argument is merged with option teal.basic_table_args and with default module arguments (hard coded in the module body). For more details, see the vignette: vignette("custom-basic-table-arguments", package = "teal.widgets").

transformators

(list of teal_transform_module) that will be applied to transform module's data input. To learn more check vignette("transform-input-data", package = "teal").

decorators

(named list of lists of teal_transform_module) optional, decorator for tables or plots included in the module output reported. The decorators are applied to the respective output objects.

See section "Decorating Module" below for more details.

Decorating Module

This module generates the following objects, which can be modified in place using decorators:

• table (TableTree - output of rtables::build_table())

A Decorator is applied to the specific output using a named list of teal_transform_module objects. The name of this list corresponds to the name of the output to which the decorator is applied. See code snippet below:

tm_t_glm_counts(
   ..., # arguments for module
   decorators = list(
     table = teal_transform_module(...) # applied only to `table` output
   )
)

For additional details and examples of decorators, refer to the vignette vignette("decorate-module-output", package = "teal.modules.clinical").

To learn more please refer to the vignette vignette("transform-module-output", package = "teal") or the teal::teal_transform_module() documentation.

Reporting

This module returns an object of class teal_module, that contains a server function. Since the server function returns a teal_report object, this makes this module reportable, which means that the reporting functionality will be turned on automatically by the teal framework.

For more information on reporting in teal, see the vignettes:

• vignette("reportable-shiny-application", package = "teal.reporter")

• vignette("adding-support-for-reporting-to-custom-modules", package = "teal")

Examples in Shinylive

example-1

Open in Shinylive

Details

• Teal module for tern::summarize_glm_count() analysis, that summarizes results of a Poisson negative binomial regression.

• The arm and stratification variables are taken from the parentname data.

See Also

summarize_glm_count()

Examples

data <- within(teal_data(), {
  ADSL <- tern::tern_ex_adsl
  ADTTE <- tern::tern_ex_adtte
})

join_keys(data) <- default_cdisc_join_keys[names(data)]

arm_ref_comp <- list(
  ACTARMCD = list(
    ref = "ARM B",
    comp = c("ARM A", "ARM C")
  ),
  ARM = list(
    ref = "B: Placebo",
    comp = c("A: Drug X", "C: Combination")
  )
)

ADSL <- data[["ADSL"]]
ADTTE <- data[["ADTTE"]]
# Initialize the teal app
app <- init(
  data = data,
  modules = modules(
    tm_t_glm_counts(
      dataname = "ADTTE",
      arm_var = choices_selected(
        variable_choices(ADTTE, c("ARM", "ARMCD", "ACTARMCD")),
        "ARMCD"
      ),
      arm_ref_comp = arm_ref_comp,
      aval_var = choices_selected(
        variable_choices(ADTTE, "AVAL"),
        "AVAL"
      ),
      strata_var = choices_selected(
        variable_choices(ADSL, "SEX"),
        NULL
      ),
      offset_var = choices_selected(
        variable_choices(ADSL, "AGE"),
        NULL
      ),
      cov_var = choices_selected(
        variable_choices(ADTTE, "SITEID"),
        NULL
      )
    )
  )
)

if (interactive()) {
  shinyApp(app$ui, app$server)
}