titeIR (version 0.1.0)

isotitesim: Simulate TITE-IR designs

Description

Simulates trials based on the TITE-IR design.

Usage

isotitesim(PI, target, n, nsim, obswin = 1, rate = 1, safety = 0.05,
  accrual = "poisson", restrict = TRUE)

Arguments

PI

A vector of true toxicity probabilities at each dose

target

Target DLT rate

n

Sample size of the trial

nsim

Number of trial replicates

obswin

The observation window with respect to which the MTD is defined

rate

Patient arrival rate: expected number of arrivals per observation window

safety

The safety factor to prevent overly aggressive escalation

accrual

Specify the accrual distribution. Can be either "poisson" or "fixed". Partial strings are also acceptable.

restrict

If TRUE, do not allow escalation immediately after a toxic outcome (require coherent escalation)

Value

Object of type isotite which provides results from TITE-IR simulations

See Also

isotitedose for dose recommendation

Examples

# NOT RUN {
isotitesim(PI = c(0.05, 0.10, 0.20, 0.30, 0.50, 0.70),
 target = 1/3, n = 24, nsim = 10, obswin = 6, rate = 12)
# }