topologyGSA (version 1.5.0)

Gene Set Analysis Exploiting Pathway Topology

Description

Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques). The package is based on the method described in Massa M.S., Chiogna M., Romualdi C. (2010) .

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Install

install.packages('topologyGSA')

Monthly Downloads

271

Version

1.5.0

License

GPL-3

Maintainer

Last Published

September 25th, 2023

Functions in topologyGSA (1.5.0)