dose_finding_fit-class

dose_finding_fit

A vector of integers representing the dose-levels under
consideration.

dose_indices

Integer, the number of patients analysed.

num_patients

vector of integers representing the dose given to the patients.

doses

vector of integers representing the toxicity status of the
patients.

The posterior mean probabilities of toxicity at doses 1:n;
a vector of numbers between 0 and 1.

prob_tox

The posterior median probabilities of toxicity at
doses 1:n; a vector of numbers between 0 and 1.

median_prob_tox

An integer representing the dose-level that is
recommended for the next patient or cohort.

recommended_dose

Object <code><a rd-options="" href="/link/crm_params?package=trialr&version=0.1.3" data-mini-rdoc="trialr::crm_params">crm_params</a></code> containing data passed to
<code><a rd-options="rstan:sampling" href="/link/sampling?package=trialr&version=0.1.3&to=rstan%3Asampling" data-mini-rdoc="rstan:sampling::sampling">sampling</a></code>.

An object of class <code><a rd-options="rstan:stanfit" href="/link/stanfit?package=trialr&version=0.1.3&to=rstan%3Astanfit" data-mini-rdoc="rstan:stanfit::stanfit">stanfit</a></code>,
containing the posterior samples.

Class of dose-finding model fit by trialr using Stan.

A collection of clinical trial designs and methods, implemented in
'rstan' and R, including: the Continual Reassessment Method by O'Quigley et
al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004)
<doi:10.1111/j.0006-341X.2004.00218.x>; and the Augmented Binary method by
Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions
to aid model-fitting and analysis. The 'rstan' implementations may also
serve as a cookbook to anyone looking to extend or embellish these models.
We hope that this package encourages the use of Bayesian methods in clinical
trials. There is a preponderance of early phase trial designs because this
is where Bayesian methods are used most. If there is a method you would like
implemented, please get in touch.

Kristian Brock

trialr

Clinical Trial Designs in 'rstan'

Trustees of Columbia University

dose_finding_fit-class function

Object <code><a rd-options='' href='crm_params'>crm_params</a></code> containing data passed to
<code><a rd-options='rstan:sampling' href='sampling'>sampling</a></code>.

An object of class <code><a rd-options='rstan:stanfit' href='stanfit'>stanfit</a></code>,
containing the posterior samples.

dose_finding_fit-class: Class of dose-finding model fit by trialr using Stan.

Description

Usage

Arguments

See Also