trialr (version 0.1.6)

efftox_priors: Simple class to hold prior hyperparameters for the EffTox model.

Description

Simple class to hold prior hyperparameters for the EffTox model.

Usage

efftox_priors(
  alpha_mean,
  alpha_sd,
  beta_mean,
  beta_sd,
  gamma_mean,
  gamma_sd,
  zeta_mean,
  zeta_sd,
  eta_mean,
  eta_sd,
  psi_mean,
  psi_sd
)

Value

list-like, instance of class efftox_priors.

Arguments

alpha_mean

The prior normal mean of the intercept term in the toxicity logit model. A number.

alpha_sd

The prior normal standard deviation of the intercept term in the toxicity logit model. A number.

beta_mean

The prior normal mean of the slope term in the toxicity logit model. A number.

beta_sd

The prior normal standard deviation of the slope term in the toxicity logit model. A number.

gamma_mean

The prior normal mean of the intercept term in the efficacy logit model. A number.

gamma_sd

The prior normal standard deviation of the intercept term in the efficacy logit model. A number.

zeta_mean

The prior normal mean of the slope term in the efficacy logit model. A number.

zeta_sd

The prior normal standard deviation of the slope term in the efficacy logit model. A number.

eta_mean

The prior normal mean of the squared term coefficient in the efficacy logit model. A number.

eta_sd

The prior normal standard deviation of the squared term coefficient in the efficacy logit model. A number.

psi_mean

The prior normal mean of the association term in the combined efficacy-toxicity model. A number.

psi_sd

The prior normal standard deviation of the association term in the combined efficacy-toxicity model. A number.

Author

Kristian Brock

References

Thall, P., & Cook, J. (2004). Dose-Finding Based on Efficacy-Toxicity Trade-Offs. Biometrics, 60(3), 684-693.

Thall, P., Herrick, R., Nguyen, H., Venier, J., & Norris, J. (2014). Effective sample size for computing prior hyperparameters in Bayesian phase I-II dose-finding. Clinical Trials, 11(6), 657-666. https://doi.org/10.1177/1740774514547397

Examples

# The priors used in Thall et al. (2014)
p <- efftox_priors(alpha_mean = -7.9593, alpha_sd = 3.5487,
                   beta_mean = 1.5482, beta_sd = 3.5018,
                   gamma_mean = 0.7367, gamma_sd = 2.5423,
                   zeta_mean = 3.4181, zeta_sd = 2.4406,
                   eta_mean = 0, eta_sd = 0.2,
                   psi_mean = 0, psi_sd = 1)
# The class exists simply to hold these twelve values.