efftox_solve_p

Calculate the p-index for EffTox utility contours so that the neutral utility
contour intersects the following points in the
Prob(Efficacy) - Prob(Toxicity) plane:
(<code>eff0</code>, 0), (1, <code>tox1</code>) and (<code>eff_star</code>, <code>tox_star</code>)

A collection of clinical trial designs and methods, implemented in
'rstan' and R, including: the Continual Reassessment Method by O'Quigley et
al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004)
<doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of
Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the
Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and
more. We provide functions to aid model-fitting and analysis.
The 'rstan' implementations may also serve as a cookbook to anyone looking
to extend or embellish these models. We hope that this package encourages
the use of Bayesian methods in clinical trials. There is a preponderance of
early phase trial designs because this is where Bayesian methods are used
most. If there is a method you would like implemented, please get in touch.

Kristian Brock

trialr

Clinical Trial Designs in 'rstan'

Trustees of Columbia University

efftox_solve_p function

<dl><dt>eff0</dt>
<dd>Efficacy probability required when toxicity is impossible;
a number between 0 and 1</dd>
<dt>tox1</dt>
<dd>Toxicity probability permitted when efficacy is guaranteed;
a number between 0 and 1</dd>
<dt>eff_star</dt>
<dd>Efficacy probability of an equi-utility third point</dd>
<dt>tox_star</dt>
<dd>Toxicity probability of an equi-utility third point</dd></dl>

Arguments

Calculate the p-index for EffTox utility contours — efftox_solve_p

<dl>

<dt>eff0</dt>
<dd>Efficacy probability required when toxicity is impossible;
a number between 0 and 1</dd>


<dt>tox1</dt>
<dd>Toxicity probability permitted when efficacy is guaranteed;
a number between 0 and 1</dd>


<dt>eff_star</dt>
<dd>Efficacy probability of an equi-utility third point</dd>


<dt>tox_star</dt>
<dd>Toxicity probability of an equi-utility third point</dd>

</dl>

efftox_solve_p: Calculate the p-index for EffTox utility contours

Description

Usage

Value

Arguments

References

Examples