trtswitch (version 0.2.2)

lrtest: Log-Rank Test of Survival Curve Difference

Description

Obtains the log-rank test using the Fleming-Harrington family of weights.

Usage

lrtest(
  data,
  rep = "",
  stratum = "",
  treat = "treat",
  time = "time",
  time2 = "",
  event = "event",
  weight = "",
  weight_readj = FALSE,
  rho1 = 0,
  rho2 = 0
)

Value

A data frame with the following variables:

• uscore: The numerator of the log-rank test statistic.

• vscore: The variance of the log-rank score test statistic.

• logRankZ: The Z-statistic value.

• logRankPValue: The two-sided p-value.

• weight_readj: Whether the weight variable will be readjusted.

• rho1: The first parameter of the Fleming-Harrington weights.

• rho2: The second parameter of the Fleming-Harrington weights.

• rep: The replication.

Arguments

data

The input data frame that contains the following variables:

• rep: The replication for by-group processing.

• stratum: The stratum.

• treat: The treatment.

• time: The follow-up time for right censored data, or the left end of each interval for counting process data.

• time2: The right end of each interval for counting process data. Intervals are assumed to be open on the left and closed on the right, and event indicates whether an event occurred at the right end of each interval.

• event: The event indicator, 1=event, 0=no event.

• weight: The weight for each observation.

rep

The name(s) of the replication variable(s) in the input data.

stratum

The name(s) of the stratum variable(s) in the input data.

treat

The name of the treatment variable in the input data.

time

The name of the time variable or the left end of each interval for counting process data in the input data.

time2

The name of the right end of each interval for counting process data in the input data.

event

The name of the event variable in the input data.

weight

The name of the weight variable in the input data.

weight_readj

Whether the weight variable at each event time will be readjusted to be proportional to the number at risk by treatment group. Defaults to FALSE.

rho1

The first parameter of the Fleming-Harrington family of weighted log-rank test. Defaults to 0 for conventional log-rank test.

rho2

The second parameter of the Fleming-Harrington family of weighted log-rank test. Defaults to 0 for conventional log-rank test.

Author

Kaifeng Lu,

Examples

df <- lrtest(data = rawdata, rep = "iterationNumber",
             stratum = "stratum", treat = "treatmentGroup",
             time = "timeUnderObservation", event = "event",
             rho1 = 0.5, rho2 = 0)
head(df)