The <code>bmt</code> data frame has 137 rows and 22 columns.

datasets

Analysis of treatment effects in clinical trials with time-to-event outcomes is complicated by intercurrent events. This package implements methods for estimating and inferring the cumulative incidence functions for time-to-event (TTE) outcomes with intercurrent events (ICE) under the five strategies outlined in the ICH E9 (R1) addendum, see Deng (2025) <doi:10.1002/sim.70091>. This package can be used for analyzing data from both randomized controlled trials and observational studies. In general, the data involve a primary outcome event and, potentially, an intercurrent event. Two data structures are allowed: competing risks, where only the time to the first event is recorded, and semicompeting risks, where the times to both the primary outcome event and intercurrent event (or censoring) are recorded. For estimation methods, users can choose nonparametric estimation (which does not use covariates) and semiparametrically efficient estimation.

Yi Zhou

tteICE

Treatment Effect Estimation for Time-to-Event Data with
Intercurrent Events

Yuhao Deng

bmt function

This data frame contains the following columns:<dl>
<dt>group</dt>
<dd>Disease Group 1-ALL, 2-AML Low Risk, 3-AML High Risk</dd><dt>t1</dt>
<dd>Time To Death Or On Study Time</dd><dt>t2</dt>
<dd>Disease Free Survival Time (Time To Relapse, Death Or End Of Study)</dd><dt>d1</dt>
<dd>Death Indicator 1-Dead 0-Alive</dd><dt>d2</dt>
<dd>Relapse Indicator 1-Relapsed, 0-Disease Free</dd><dt>d3</dt>
<dd>Disease Free Survival Indicator 1-Dead Or Relapsed, 0-Alive Disease Free)</dd><dt>ta</dt>
<dd>Time To Acute Graft-Versus-Host Disease</dd><dt>da</dt>
<dd>Acute GVHD Indicator 1-Developed Acute GVHD 0-Never Developed Acute GVHD)</dd><dt>tc</dt>
<dd>Time To Chronic Graft-Versus-Host Disease</dd><dt>dc</dt>
<dd>Chronic GVHD Indicator 1-Developed Chronic GVHD 0-Never Developed Chronic GVHD</dd><dt>tp</dt>
<dd>Time To Platelet Recovery</dd><dt>dp</dt>
<dd>Platelet Recovery Indicator 1-Platelets Returned To Normal, 0-Platelets Never Returned to Normal</dd><dt>z1</dt>
<dd>Patient Age In Years</dd><dt>z2</dt>
<dd>Donor Age In Years</dd><dt>z3</dt>
<dd>Patient Sex: 1-Male, 0-Female</dd><dt>z4</dt>
<dd>Donor Sex: 1-Male, 0-Female</dd><dt>z5</dt>
<dd>Patient CMV Status: 1-CMV Positive, 0-CMV Negative</dd><dt>z6</dt>
<dd>Donor CMVStatus: 1-CMV Positive, 0-CMV Negative</dd><dt>z7</dt>
<dd>Waiting Time to Transplant In Days</dd><dt>z8</dt>
<dd>FAB: 1-FAB Grade 4 Or 5 and AML, 0-Otherwise</dd><dt>z9</dt>
<dd>Hospital: 1-The Ohio State University, 2-Alferd, 3-St. Vincent, 4-Hahnemann</dd><dt>z10</dt>
<dd>MTX used as a Graft-Versus-Host-Prophylactic: 1-Yes 0-No</dd>
</dl>

Format

Data from Section 1.3 of Klein and Moeschberger (1997) — bmt

This data frame contains the following columns:<dl>
<dt>group</dt>
<dd>Disease Group 1-ALL, 2-AML Low Risk, 3-AML High Risk</dd>

<dt>t1</dt>
<dd>Time To Death Or On Study Time</dd>

<dt>t2</dt>
<dd>Disease Free Survival Time (Time To Relapse, Death Or End Of Study)</dd>

<dt>d1</dt>
<dd>Death Indicator 1-Dead 0-Alive</dd>

<dt>d2</dt>
<dd>Relapse Indicator 1-Relapsed, 0-Disease Free</dd>

<dt>d3</dt>
<dd>Disease Free Survival Indicator 1-Dead Or Relapsed, 0-Alive Disease Free)</dd>

<dt>ta</dt>
<dd>Time To Acute Graft-Versus-Host Disease</dd>

<dt>da</dt>
<dd>Acute GVHD Indicator 1-Developed Acute GVHD 0-Never Developed Acute GVHD)</dd>

<dt>tc</dt>
<dd>Time To Chronic Graft-Versus-Host Disease</dd>

<dt>dc</dt>
<dd>Chronic GVHD Indicator 1-Developed Chronic GVHD 0-Never Developed Chronic GVHD</dd>

<dt>tp</dt>
<dd>Time To Platelet Recovery</dd>

<dt>dp</dt>
<dd>Platelet Recovery Indicator 1-Platelets Returned To Normal, 0-Platelets Never Returned to Normal</dd>

<dt>z1</dt>
<dd>Patient Age In Years</dd>

<dt>z2</dt>
<dd>Donor Age In Years</dd>

<dt>z3</dt>
<dd>Patient Sex: 1-Male, 0-Female</dd>

<dt>z4</dt>
<dd>Donor Sex: 1-Male, 0-Female</dd>

<dt>z5</dt>
<dd>Patient CMV Status: 1-CMV Positive, 0-CMV Negative</dd>

<dt>z6</dt>
<dd>Donor CMVStatus: 1-CMV Positive, 0-CMV Negative</dd>

<dt>z7</dt>
<dd>Waiting Time to Transplant In Days</dd>

<dt>z8</dt>
<dd>FAB: 1-FAB Grade 4 Or 5 and AML, 0-Otherwise</dd>

<dt>z9</dt>
<dd>Hospital: 1-The Ohio State University, 2-Alferd, 3-St. Vincent, 4-Hahnemann</dd>

<dt>z10</dt>
<dd>MTX used as a Graft-Versus-Host-Prophylactic: 1-Yes 0-No</dd>


</dl>

bmt: Data from Section 1.3 of Klein and Moeschberger (1997)

Description

Usage

Arguments

Format

Examples