compute_extended_ratios

Computes 76 additional ratios not provided by the Nightingale platform. These
include lipid fractions in HDL, LDL, VLDL, and total serum, as well as
cholesterol fractions, and omega to polyunsaturated fatty acid ratios. See
<code>nmr_info</code> for details.

A suite of utilities for working with the UK Biobank
<https://www.ukbiobank.ac.uk/> Nuclear Magnetic Resonance spectroscopy (NMR)
metabolomics data <https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=220>.
Includes functions for extracting biomarkers from decoded UK Biobank field
data, removing unwanted technical variation from biomarker concentrations,
computing an extended set of lipid, fatty acid, and cholesterol fractions,
and for re-deriving composite biomarkers and ratios after adjusting data
for unwanted biological variation. For further details on methods see
Ritchie SC et al. Sci Data (2023) <doi:10.1038/s41597-023-01949-y>.

Scott Ritchie

ukbnmr

Removal of Unwanted Technical Variation from UK Biobank NMR
Metabolomics Biomarker Data

compute_extended_ratios function

<dl><dt>x</dt>
<dd><code>data.frame</code> containing NMR metabolomics data from UK Biobank.
May either be raw field data output by
<a href="https://biobank.ctsu.ox.ac.uk/crystal/exinfo.cgi?src=accessing_data_guide">ukbconv</a>
or data with column names corresponding to biomarkers listed in <code>nmr_info</code>.</dd></dl>

Arguments

Compute extended set of biomarker ratios — compute_extended_ratios

<dl>

<dt>x</dt>
<dd><code>data.frame</code> containing NMR metabolomics data from UK Biobank.
May either be raw field data output by
<a href='https://biobank.ctsu.ox.ac.uk/crystal/exinfo.cgi?src=accessing_data_guide'>ukbconv</a>
or data with column names corresponding to biomarkers listed in <code>nmr_info</code>.</dd>

</dl>

compute_extended_ratios: Compute extended set of biomarker ratios

Description

Usage

Value

Arguments

Details

See Also

Examples