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upndown (version 0.3.0)

Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Description

Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Recent applied UD tutorial: Oron et al., 2022 . Recent methodological overview: Oron and Flournoy, 2024 .

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Version

Install

install.packages('upndown')

Monthly Downloads

126

Version

0.3.0

License

GPL-2

Maintainer

Assaf P. Oron

Last Published

June 16th, 2025

Functions in upndown (0.3.0)

krow

Up-and-Down Design Rules for use in Dose-Finding Simulator
k2targ

Up-and-Down Target Calculation and Design Guidance
reversmean

Reversal-anchored averaging estimators for Up-and-Down
dfboot

Generic percentile dose-response / dose-finding bootstrap routine
drplot

Visualizing the dose-response summary of an up-and-down experiment
dixonmood

Original Dixon and Mood (1948) point estimate
dfsim

Generalized Dose-Finding Ensemble Simulator
dynamean

Up-and-Down target-dose averaging estimate, with dynamic cutoff-point
udplot

Visualizing the time series of an up-and-down experiment
validUDinput

Data Validation Utilities for upndown
udest

Centered-Isotonic-Regression (CIR) Estimate for the Up-and-Down Target Dose
pivec

Key Probability Vectors of Up-and-Down Designs
bcdmat

Transition Probability Matrices for Up-and-Down Designs