get_nonparametricTTS

numeric vector of viral load measurements.

numeric value for the suppression threshold: measurements below this value will be assumed to represent viral suppression. Typically this would be the detection threshold of the assay. Default value is 20.

suppression_threshold

numeric vector indicating the time when vl measurements were taken.

time

numeric value indicating the number of interpolation points to be considered.

npoints

This function computes the non-parametric form of the time to suppression

Analyzes longitudinal data of HIV decline in patients on antiretroviral therapy using the canonical biphasic exponential decay model (pioneered, for example, by work in Perelson et al. (1997) <doi:10.1038/387188a0>; and Wu and Ding (1999) <doi:10.1111/j.0006-341X.1999.00410.x>). Model fitting and parameter estimation are performed, with additional options to calculate the time to viral suppression. Plotting and summary tools are also provided for fast assessment of model results.

get_nonparametricTTS: Non-parametric TTS function

Description

Usage

Arguments