get_parametricTTS

named vector of all parameters needed to compute the suppression model, V(t)

params

specifies which function should be used to calculate the root: biphasic or single phase.

rootfunction

suppression threshold: measurements below this value will be assumed to represent viral suppression. Typically this would be the detection threshold of the assay. Default value is 20.

suppression_threshold

numeric value indicating the maximum time that will be considered. Default value is 365.

uppertime

This function computes the parametric form of the time to suppression

Analyzes longitudinal data of HIV decline in patients on antiretroviral therapy using the canonical biphasic exponential decay model (pioneered, for example, by work in Perelson et al. (1997) <doi:10.1038/387188a0>; and Wu and Ding (1999) <doi:10.1111/j.0006-341X.1999.00410.x>). Model fitting and parameter estimation are performed, with additional options to calculate the time to viral suppression. Plotting and summary tools are also provided for fast assessment of model results.

get_parametricTTS: Parametric TTS function

Description

Usage

Arguments